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Senior Research Specialist I

Princeton, NJ
Princeton University


The Ayroles laboratory at the Lewis-Sigler Institute for Integrative Genomics seeks applicants for a Senior Research Specialist position. We are looking for creative and passionate people at various stage in their careers. The research scientist will work closely with the PI and a number of postdocs and graduate students on data generation and protocol development. The candidate will have the opportunity to co-author publications and, depending on their background and experience, craft their own research projects. Training and guidance will be provided for those aspects of the job in which the candidate is lacking sufficient expertise. The rank and salary will be commensurate with experience.

The position is open and review of applications will begin immediately. This is a one-year term position, with the possibility of renewal contingent upon continued funding and satisfactory performance.

Lab overview:

Our group takes a multi-disciplinary approach to study the biological basis for individual variation. We seek to understand how genes interact with each other and their environment to shape variation between individuals. Despite considerable effort and resources, little progress has been made in human genetics towards understanding the genetic basis for diseases that are clearly associated with environmental exposure (e.g. diet, toxins) but have a clear heritable component (e.g. cardiovascular disease, asthma). It is well established in quantitative genetics that stressful environmental exposure tends to increase the phenotypic variance of a population. In other words, stress tends to decrease organismal robustness. But how and why? And most importantly, why do some individuals appear to be more sensitive than others to such environmental perturbations? To address this question, we use model systems such as Drosophila to systematically delineate how individual respond to changing conditions under both normal and stressful environments. Our goal is to (1) achieve a better understanding of differential response activities at the behavioral, transcriptional and metabolic level and (2) identify and characterize context-specific responses - especially with respect to genetic background.

Various projects in the lab are unified by our interest in understanding the interplay between genetic and environment variation whether we are pushing the boundaries of what can be achieved with model organism or translating our findings to human biology.

We are looking for a highly motivated, well-organized laboratory researcher who can independently oversee research activities within the laboratory as well as assist group members with their projects. The candidate will carry out large-scale genomics projects and to support various lab activities. Princeton is genuinely dedicated to undergraduate education and in addition to research, the candidate will also assist in training undergraduate students.

Specific duties include:
- Managing various Drosophila projects.

- Developing new protocols to enable cutting edge applications of sequencing technology.

- Preparing sequencing libraries.

- Performing quality control of input samples and sequencing libraries.

- Training technicians, students, and postdocs on these methods and protocols.

- Managing data.

Essential qualifications:

- At least 2 to 4 years of academic research and/or professional experience in general modern molecular biology techniques.

- Ability to work well with others in a team environment.

- Ability to multi-task and prioritize in an environment with multiple demands and ongoing projects.

- Ability to lead a project independently and trouble shoot as needed.

- Ability to work under deadlines with general guidance is essential.

Required education:

- A Master’s or Ph.D. degree or equivalent in biological sciences or related field.

Preferred qualifications:

- Experience with teaching or training others in a laboratory setting.

- Experience working with Drosophila would be a plus.

- General computer skills and experience with databases and scientific applications.

- Strong analytical skills and excellent judgment.

The ideal candidate is one who seeks professional development as a scientist and is therefore interested in reading the current scientific literature and conducting an independent research project.

Princeton University is an Equal Opportunity/Affirmative Action Employer and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender identity or expression, national origin, disability status, protected veteran status, or any other characteristic protected by law. EEO IS THE LAW.